CD4-guided scheduled treatment interruptions compared with continuous therapy for patients infected with HIV-1 : results of the staccato randomised trial
Identifieur interne : 00A062 ( Main/Exploration ); précédent : 00A061; suivant : 00A063CD4-guided scheduled treatment interruptions compared with continuous therapy for patients infected with HIV-1 : results of the staccato randomised trial
Auteurs : Jintanat Ananworanich [Thaïlande] ; Angèle Gayet-Ageron [Suisse] ; Michelle Le Braz [Suisse] ; Wisit Prasithsirikul [Thaïlande] ; Ploenchan Chetchotisakd [Thaïlande] ; Sasisopin Kiertiburanakul [Thaïlande] ; Warangkana Munsakul [Thaïlande] ; Phitsanu Raksakulkarn [Thaïlande] ; Somboon Tansuphasawasdikul [Thaïlande] ; Sunee Sirivkhayakul [Thaïlande] ; Matthias Cavassini [Suisse] ; Urs Karrer [Suisse] ; Daniel Genne [Suisse] ; Reto Nuesch [Suisse] ; Pietro Vernazza [Suisse] ; Enos Bernasconi [Suisse] ; Dominic Leduc [France] ; Claudette Satchell [Australie] ; Sabine Yerly [Suisse] ; Luc Perrin [Suisse] ; Andrew Hill [Royaume-Uni] ; Thomas Perneger [Suisse] ; Praphan Phanuphak [Thaïlande] ; Hansjakob Furrer [Suisse] ; David Cooper [Thaïlande, Australie] ; Kiat Ruxrungtham [Thaïlande] ; Bernard Hirschel [Suisse]Source :
- Lancet : (British edition) [ 0140-6736 ] ; 2006.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Médecine.
English descriptors
- KwdEn :
Abstract
Background Stopping antiretroviral therapy in patients with HIV-1 infection can reduce costs and side-effects, but carries the risk of increased immune suppression and emergence of resistance. Methods 430 patients with CD4-positive T-lymphocyte (CD4) counts greater than 350 cells per pL, and viral load less than 50 copies per mL were randomised to continued therapy (n=146) or scheduled treatment interruptions (n=284). Median time on randomised treatment was 21.9 months (range 16.4-25.3). Primary endpoints were proportion of patients with viral load less than 50 copies per mL at the end of the trial, and amount of drugs used. Analysis was intention-to-treat. This study is registered at ClinicalTrials.gov with the identifier NCT00113126. Findings Drug savings in the scheduled treatment interruption group, compared with continuous treatment, amounted to 61.5%. 257 of 284 (90.5%) patients in the scheduled treatment interruption group reached a viral load less than 50 copies per mL, compared with 134 of 146 (91.8%) in the continued treatment group (difference 1.3%, 95% CI-4.3 to 6.9, p=0.90). No AIDS-defining events occurred. Diarrhoea and neuropathy were more frequent with continuous treatment; candidiasis was more frequent with scheduled treatment interruption. Ten patients (2.3%) had resistance mutations, with no significant differences between groups. Interpretation Drug savings with scheduled treatment interruption were substantial, and no evidence of increased treatment resistance emerged. Treatment-related adverse events were more frequent with continuous treatment, but low CD4 counts and minor manifestations of HIV infection were more frequent with scheduled treatment interruption.
Affiliations:
- Australie, France, Royaume-Uni, Suisse, Thaïlande
- Canton de Berne, Canton de Vaud, Canton de Zurich, Nouvelle-Galles du Sud
- Berne, Lausanne, Sydney, Zurich
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first="Kiat" last="Ruxrungtham">Kiat Ruxrungtham</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>HIV Netherlands Australia Thailand Research Collaboration</s1><s2>Bangkok</s2><s3>THA</s3><sZ>1 aut.</sZ><sZ>23 aut.</sZ><sZ>25 aut.</sZ><sZ>26 aut.</sZ></inist:fA14><country>Thaïlande</country><wicri:noRegion>HIV Netherlands Australia Thailand Research Collaboration</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="09"><s1>Chulalongkorn University</s1><s2>Bangkok</s2><s3>THA</s3><sZ>10 aut.</sZ><sZ>26 aut.</sZ></inist:fA14><country>Thaïlande</country><wicri:noRegion>Chulalongkorn University</wicri:noRegion></affiliation></author><author><name sortKey="Hirschel, Bernard" sort="Hirschel, Bernard" uniqKey="Hirschel B" first="Bernard" last="Hirschel">Bernard Hirschel</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Division of Infectious Diseases, Geneva University Hospital</s1><s2>1211 Geneva</s2><s3>CHE</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>19 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scheduled treatment interruptions compared with continuous therapy for patients infected with HIV-1 : results of the staccato randomised trial</title><author><name sortKey="Ananworanich, Jintanat" sort="Ananworanich, Jintanat" uniqKey="Ananworanich J" first="Jintanat" last="Ananworanich">Jintanat Ananworanich</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>HIV Netherlands Australia Thailand Research Collaboration</s1><s2>Bangkok</s2><s3>THA</s3><sZ>1 aut.</sZ><sZ>23 aut.</sZ><sZ>25 aut.</sZ><sZ>26 aut.</sZ></inist:fA14><country>Thaïlande</country><wicri:noRegion>HIV Netherlands Australia Thailand Research Collaboration</wicri:noRegion></affiliation></author><author><name sortKey="Gayet Ageron, Angele" sort="Gayet Ageron, Angele" uniqKey="Gayet Ageron A" first="Angèle" last="Gayet-Ageron">Angèle Gayet-Ageron</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Division of Infectious Diseases, Geneva University Hospital</s1><s2>1211 Geneva</s2><s3>CHE</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ><sZ>22 aut.</sZ><sZ>27 aut.</sZ></inist:fA14><country>Suisse</country><wicri:noRegion>1211 Geneva</wicri:noRegion></affiliation></author><author><name sortKey="Le Braz, Michelle" sort="Le Braz, Michelle" uniqKey="Le Braz M" first="Michelle" last="Le Braz">Michelle Le Braz</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Division of Infectious Diseases, Geneva University Hospital</s1><s2>1211 Geneva</s2><s3>CHE</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ><sZ>22 aut.</sZ><sZ>27 aut.</sZ></inist:fA14><country>Suisse</country><wicri:noRegion>1211 Geneva</wicri:noRegion></affiliation></author><author><name sortKey="Prasithsirikul, Wisit" sort="Prasithsirikul, Wisit" uniqKey="Prasithsirikul W" first="Wisit" last="Prasithsirikul">Wisit Prasithsirikul</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Bamrasnaradura Institute</s1><s2>Nonthaburi</s2><s3>THA</s3><sZ>4 aut.</sZ></inist:fA14><country>Thaïlande</country><wicri:noRegion>Bamrasnaradura Institute</wicri:noRegion></affiliation></author><author><name sortKey="Chetchotisakd, Ploenchan" sort="Chetchotisakd, Ploenchan" uniqKey="Chetchotisakd P" first="Ploenchan" last="Chetchotisakd">Ploenchan Chetchotisakd</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Khon Kaen University</s1><s2>Khon Kaen</s2><s3>THA</s3><sZ>5 aut.</sZ></inist:fA14><country>Thaïlande</country><wicri:noRegion>Khon Kaen University</wicri:noRegion></affiliation></author><author><name sortKey="Kiertiburanakul, Sasisopin" sort="Kiertiburanakul, Sasisopin" uniqKey="Kiertiburanakul S" first="Sasisopin" last="Kiertiburanakul">Sasisopin Kiertiburanakul</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Ramathibodi Hospital, Mahidol University</s1><s2>Bangkok</s2><s3>THA</s3><sZ>6 aut.</sZ></inist:fA14><country>Thaïlande</country><wicri:noRegion>Bangkok</wicri:noRegion></affiliation></author><author><name sortKey="Munsakul, Warangkana" sort="Munsakul, Warangkana" uniqKey="Munsakul W" first="Warangkana" last="Munsakul">Warangkana Munsakul</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Bangkok Metropolitan Administration Medical College and Vajira Hospital</s1><s2>Bangkok</s2><s3>THA</s3><sZ>7 aut.</sZ></inist:fA14><country>Thaïlande</country><wicri:noRegion>Bangkok Metropolitan Administration Medical College and Vajira Hospital</wicri:noRegion></affiliation></author><author><name sortKey="Raksakulkarn, Phitsanu" sort="Raksakulkarn, Phitsanu" uniqKey="Raksakulkarn P" first="Phitsanu" last="Raksakulkarn">Phitsanu Raksakulkarn</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Sanpatong Hospital</s1><s2>Chiang Mai</s2><s3>THA</s3><sZ>8 aut.</sZ></inist:fA14><country>Thaïlande</country><wicri:noRegion>Sanpatong Hospital</wicri:noRegion></affiliation></author><author><name sortKey="Tansuphasawasdikul, Somboon" sort="Tansuphasawasdikul, Somboon" uniqKey="Tansuphasawasdikul S" first="Somboon" last="Tansuphasawasdikul">Somboon Tansuphasawasdikul</name><affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Buddhachinnaraj Hospital</s1><s2>Phitsanulok</s2><s3>THA</s3><sZ>9 aut.</sZ></inist:fA14><country>Thaïlande</country><wicri:noRegion>Buddhachinnaraj Hospital</wicri:noRegion></affiliation></author><author><name sortKey="Sirivkhayakul, Sunee" sort="Sirivkhayakul, Sunee" uniqKey="Sirivkhayakul S" first="Sunee" last="Sirivkhayakul">Sunee Sirivkhayakul</name><affiliation wicri:level="1"><inist:fA14 i1="09"><s1>Chulalongkorn University</s1><s2>Bangkok</s2><s3>THA</s3><sZ>10 aut.</sZ><sZ>26 aut.</sZ></inist:fA14><country>Thaïlande</country><wicri:noRegion>Chulalongkorn University</wicri:noRegion></affiliation></author><author><name sortKey="Cavassini, Matthias" sort="Cavassini, Matthias" uniqKey="Cavassini M" first="Matthias" last="Cavassini">Matthias Cavassini</name><affiliation wicri:level="3"><inist:fA14 i1="10"><s1>University Hospital</s1><s2>Lausanne</s2><s3>CHE</s3><sZ>11 aut.</sZ></inist:fA14><country>Suisse</country><placeName><settlement type="city">Lausanne</settlement><region nuts="3" type="region">Canton de Vaud</region></placeName></affiliation></author><author><name sortKey="Karrer, Urs" sort="Karrer, Urs" uniqKey="Karrer U" first="Urs" last="Karrer">Urs Karrer</name><affiliation wicri:level="3"><inist:fA14 i1="11"><s1>University Hospital</s1><s2>Zürich</s2><s3>CHE</s3><sZ>12 aut.</sZ></inist:fA14><country>Suisse</country><placeName><settlement type="city">Zurich</settlement><region nuts="3" type="region">Canton de Zurich</region></placeName></affiliation></author><author><name sortKey="Genne, Daniel" sort="Genne, Daniel" uniqKey="Genne D" first="Daniel" last="Genne">Daniel Genne</name><affiliation wicri:level="1"><inist:fA14 i1="12"><s1>La Chaux-de-Fonds Hospital</s1><s2>La Chaux-de-Fonds</s2><s3>CHE</s3><sZ>13 aut.</sZ></inist:fA14><country>Suisse</country><wicri:noRegion>La Chaux-de-Fonds Hospital</wicri:noRegion></affiliation></author><author><name sortKey="Nuesch, Reto" sort="Nuesch, Reto" uniqKey="Nuesch R" first="Reto" last="Nuesch">Reto Nuesch</name><affiliation wicri:level="1"><inist:fA14 i1="13"><s1>Universitatsspital Basel</s1><s2>Basel</s2><s3>CHE</s3><sZ>14 aut.</sZ></inist:fA14><country>Suisse</country><wicri:noRegion>Universitatsspital Basel</wicri:noRegion></affiliation></author><author><name sortKey="Vernazza, Pietro" sort="Vernazza, Pietro" uniqKey="Vernazza P" first="Pietro" last="Vernazza">Pietro Vernazza</name><affiliation wicri:level="1"><inist:fA14 i1="14"><s1>Kantonsspital St Gallen</s1><s2>St Gallen</s2><s3>CHE</s3><sZ>15 aut.</sZ></inist:fA14><country>Suisse</country><wicri:noRegion>Kantonsspital St Gallen</wicri:noRegion></affiliation></author><author><name sortKey="Bernasconi, Enos" sort="Bernasconi, Enos" uniqKey="Bernasconi E" first="Enos" last="Bernasconi">Enos Bernasconi</name><affiliation wicri:level="1"><inist:fA14 i1="15"><s1>Ospedale Civico</s1><s2>Lugano</s2><s3>CHE</s3><sZ>16 aut.</sZ></inist:fA14><country>Suisse</country><wicri:noRegion>Ospedale Civico</wicri:noRegion></affiliation></author><author><name sortKey="Leduc, Dominic" sort="Leduc, Dominic" uniqKey="Leduc D" first="Dominic" last="Leduc">Dominic Leduc</name><affiliation wicri:level="1"><inist:fA14 i1="16"><s1>Hôpital d'Annemasse</s1><s2>Annemasse</s2><s3>FRA</s3><sZ>17 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Annemasse</wicri:noRegion><wicri:noRegion>Hôpital d'Annemasse</wicri:noRegion><wicri:noRegion>Hôpital d'Annemasse</wicri:noRegion></affiliation></author><author><name sortKey="Satchell, Claudette" sort="Satchell, Claudette" uniqKey="Satchell C" first="Claudette" last="Satchell">Claudette Satchell</name><affiliation wicri:level="3"><inist:fA14 i1="17"><s1>The National Centre in HIV Epidemiology and Clinical Research</s1><s2>Sydney</s2><s3>AUS</s3><sZ>18 aut.</sZ><sZ>25 aut.</sZ></inist:fA14><country>Australie</country><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Yerly, Sabine" sort="Yerly, Sabine" uniqKey="Yerly S" first="Sabine" last="Yerly">Sabine Yerly</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Division of Infectious Diseases, Geneva University Hospital</s1><s2>1211 Geneva</s2><s3>CHE</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ><sZ>22 aut.</sZ><sZ>27 aut.</sZ></inist:fA14><country>Suisse</country><wicri:noRegion>1211 Geneva</wicri:noRegion></affiliation></author><author><name sortKey="Perrin, Luc" sort="Perrin, Luc" uniqKey="Perrin L" first="Luc" last="Perrin">Luc Perrin</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Division of Infectious Diseases, Geneva University Hospital</s1><s2>1211 Geneva</s2><s3>CHE</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ><sZ>22 aut.</sZ><sZ>27 aut.</sZ></inist:fA14><country>Suisse</country><wicri:noRegion>1211 Geneva</wicri:noRegion></affiliation></author><author><name sortKey="Hill, Andrew" sort="Hill, Andrew" uniqKey="Hill A" first="Andrew" last="Hill">Andrew Hill</name><affiliation wicri:level="1"><inist:fA14 i1="18"><s1>University of Liverpool</s1><s2>Liverpool</s2><s3>GBR</s3><sZ>21 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>University of Liverpool</wicri:noRegion></affiliation></author><author><name sortKey="Perneger, Thomas" sort="Perneger, Thomas" uniqKey="Perneger T" first="Thomas" last="Perneger">Thomas Perneger</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Division of Infectious Diseases, Geneva University Hospital</s1><s2>1211 Geneva</s2><s3>CHE</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ><sZ>22 aut.</sZ><sZ>27 aut.</sZ></inist:fA14><country>Suisse</country><wicri:noRegion>1211 Geneva</wicri:noRegion></affiliation></author><author><name sortKey="Phanuphak, Praphan" sort="Phanuphak, Praphan" uniqKey="Phanuphak P" first="Praphan" last="Phanuphak">Praphan Phanuphak</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>HIV Netherlands Australia Thailand Research Collaboration</s1><s2>Bangkok</s2><s3>THA</s3><sZ>1 aut.</sZ><sZ>23 aut.</sZ><sZ>25 aut.</sZ><sZ>26 aut.</sZ></inist:fA14><country>Thaïlande</country><wicri:noRegion>HIV Netherlands Australia Thailand Research Collaboration</wicri:noRegion></affiliation></author><author><name sortKey="Furrer, Hansjakob" sort="Furrer, Hansjakob" uniqKey="Furrer H" first="Hansjakob" last="Furrer">Hansjakob Furrer</name><affiliation wicri:level="3"><inist:fA14 i1="19"><s1>University Hospital</s1><s2>Bern</s2><s3>CHE</s3><sZ>24 aut.</sZ></inist:fA14><country>Suisse</country><placeName><settlement type="city">Berne</settlement><region type="région" nuts="3">Canton de Berne</region></placeName></affiliation></author><author><name sortKey="Cooper, David" sort="Cooper, David" uniqKey="Cooper D" first="David" last="Cooper">David Cooper</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>HIV Netherlands Australia Thailand Research Collaboration</s1><s2>Bangkok</s2><s3>THA</s3><sZ>1 aut.</sZ><sZ>23 aut.</sZ><sZ>25 aut.</sZ><sZ>26 aut.</sZ></inist:fA14><country>Thaïlande</country><wicri:noRegion>HIV Netherlands Australia Thailand Research Collaboration</wicri:noRegion></affiliation><affiliation wicri:level="3"><inist:fA14 i1="17"><s1>The National Centre in HIV Epidemiology and Clinical Research</s1><s2>Sydney</s2><s3>AUS</s3><sZ>18 aut.</sZ><sZ>25 aut.</sZ></inist:fA14><country>Australie</country><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Ruxrungtham, Kiat" sort="Ruxrungtham, Kiat" uniqKey="Ruxrungtham K" first="Kiat" last="Ruxrungtham">Kiat Ruxrungtham</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>HIV Netherlands Australia Thailand Research Collaboration</s1><s2>Bangkok</s2><s3>THA</s3><sZ>1 aut.</sZ><sZ>23 aut.</sZ><sZ>25 aut.</sZ><sZ>26 aut.</sZ></inist:fA14><country>Thaïlande</country><wicri:noRegion>HIV Netherlands Australia Thailand Research Collaboration</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="09"><s1>Chulalongkorn University</s1><s2>Bangkok</s2><s3>THA</s3><sZ>10 aut.</sZ><sZ>26 aut.</sZ></inist:fA14><country>Thaïlande</country><wicri:noRegion>Chulalongkorn University</wicri:noRegion></affiliation></author><author><name sortKey="Hirschel, Bernard" sort="Hirschel, Bernard" uniqKey="Hirschel B" first="Bernard" last="Hirschel">Bernard Hirschel</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Division of Infectious Diseases, Geneva University Hospital</s1><s2>1211 Geneva</s2><s3>CHE</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ><sZ>22 aut.</sZ><sZ>27 aut.</sZ></inist:fA14><country>Suisse</country><wicri:noRegion>1211 Geneva</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">Lancet : (British edition)</title><title level="j" type="abbreviated">Lancet : (Br. ed.)</title><idno type="ISSN">0140-6736</idno><imprint><date when="2006">2006</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Lancet : (British edition)</title><title level="j" type="abbreviated">Lancet : (Br. ed.)</title><idno type="ISSN">0140-6736</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>AIDS</term><term>Clinical trial</term><term>Comparative study</term><term>Continuous</term><term>Guidance</term><term>Medicine</term><term>Result</term><term>Structured treatment interruption</term><term>T-Lymphocyte</term><term>Treatment</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>SIDA</term><term>Lymphocyte T</term><term>Guidage</term><term>Interruption structurée du traitement</term><term>Etude comparative</term><term>Continu</term><term>Traitement</term><term>Résultat</term><term>Essai clinique</term><term>Médecine</term><term>Antigène CD4</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Médecine</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Background Stopping antiretroviral therapy in patients with HIV-1 infection can reduce costs and side-effects, but carries the risk of increased immune suppression and emergence of resistance. Methods 430 patients with CD4-positive T-lymphocyte (CD4) counts greater than 350 cells per pL, and viral load less than 50 copies per mL were randomised to continued therapy (n=146) or scheduled treatment interruptions (n=284). Median time on randomised treatment was 21.9 months (range 16.4-25.3). Primary endpoints were proportion of patients with viral load less than 50 copies per mL at the end of the trial, and amount of drugs used. Analysis was intention-to-treat. This study is registered at ClinicalTrials.gov with the identifier NCT00113126. Findings Drug savings in the scheduled treatment interruption group, compared with continuous treatment, amounted to 61.5%. 257 of 284 (90.5%) patients in the scheduled treatment interruption group reached a viral load less than 50 copies per mL, compared with 134 of 146 (91.8%) in the continued treatment group (difference 1.3%, 95% CI-4.3 to 6.9, p=0.90). No AIDS-defining events occurred. Diarrhoea and neuropathy were more frequent with continuous treatment; candidiasis was more frequent with scheduled treatment interruption. Ten patients (2.3%) had resistance mutations, with no significant differences between groups. Interpretation Drug savings with scheduled treatment interruption were substantial, and no evidence of increased treatment resistance emerged. Treatment-related adverse events were more frequent with continuous treatment, but low CD4 counts and minor manifestations of HIV infection were more frequent with scheduled treatment interruption.</div></front></TEI><affiliations><list><country><li>Australie</li><li>France</li><li>Royaume-Uni</li><li>Suisse</li><li>Thaïlande</li></country><region><li>Canton de Berne</li><li>Canton de Vaud</li><li>Canton de Zurich</li><li>Nouvelle-Galles du Sud</li></region><settlement><li>Berne</li><li>Lausanne</li><li>Sydney</li><li>Zurich</li></settlement></list><tree><country name="Thaïlande"><noRegion><name sortKey="Ananworanich, Jintanat" sort="Ananworanich, Jintanat" uniqKey="Ananworanich J" first="Jintanat" last="Ananworanich">Jintanat Ananworanich</name></noRegion><name sortKey="Chetchotisakd, Ploenchan" sort="Chetchotisakd, Ploenchan" uniqKey="Chetchotisakd P" first="Ploenchan" last="Chetchotisakd">Ploenchan Chetchotisakd</name><name sortKey="Cooper, David" sort="Cooper, David" uniqKey="Cooper D" first="David" last="Cooper">David Cooper</name><name sortKey="Kiertiburanakul, Sasisopin" sort="Kiertiburanakul, Sasisopin" uniqKey="Kiertiburanakul S" first="Sasisopin" last="Kiertiburanakul">Sasisopin Kiertiburanakul</name><name sortKey="Munsakul, Warangkana" sort="Munsakul, Warangkana" uniqKey="Munsakul W" first="Warangkana" last="Munsakul">Warangkana Munsakul</name><name sortKey="Phanuphak, Praphan" sort="Phanuphak, Praphan" uniqKey="Phanuphak P" first="Praphan" last="Phanuphak">Praphan Phanuphak</name><name sortKey="Prasithsirikul, Wisit" sort="Prasithsirikul, Wisit" uniqKey="Prasithsirikul W" first="Wisit" last="Prasithsirikul">Wisit Prasithsirikul</name><name sortKey="Raksakulkarn, Phitsanu" sort="Raksakulkarn, Phitsanu" uniqKey="Raksakulkarn P" first="Phitsanu" last="Raksakulkarn">Phitsanu Raksakulkarn</name><name sortKey="Ruxrungtham, Kiat" sort="Ruxrungtham, Kiat" uniqKey="Ruxrungtham K" first="Kiat" last="Ruxrungtham">Kiat Ruxrungtham</name><name sortKey="Ruxrungtham, Kiat" sort="Ruxrungtham, Kiat" uniqKey="Ruxrungtham K" first="Kiat" last="Ruxrungtham">Kiat Ruxrungtham</name><name sortKey="Sirivkhayakul, Sunee" sort="Sirivkhayakul, Sunee" uniqKey="Sirivkhayakul S" first="Sunee" last="Sirivkhayakul">Sunee Sirivkhayakul</name><name sortKey="Tansuphasawasdikul, Somboon" sort="Tansuphasawasdikul, Somboon" uniqKey="Tansuphasawasdikul S" first="Somboon" last="Tansuphasawasdikul">Somboon Tansuphasawasdikul</name></country><country name="Suisse"><noRegion><name sortKey="Gayet Ageron, Angele" sort="Gayet Ageron, Angele" uniqKey="Gayet Ageron A" first="Angèle" last="Gayet-Ageron">Angèle Gayet-Ageron</name></noRegion><name sortKey="Bernasconi, Enos" sort="Bernasconi, Enos" uniqKey="Bernasconi E" first="Enos" last="Bernasconi">Enos Bernasconi</name><name sortKey="Cavassini, Matthias" sort="Cavassini, Matthias" uniqKey="Cavassini M" first="Matthias" last="Cavassini">Matthias Cavassini</name><name sortKey="Furrer, Hansjakob" sort="Furrer, Hansjakob" uniqKey="Furrer H" first="Hansjakob" last="Furrer">Hansjakob Furrer</name><name sortKey="Genne, Daniel" sort="Genne, Daniel" uniqKey="Genne D" first="Daniel" last="Genne">Daniel Genne</name><name sortKey="Hirschel, Bernard" sort="Hirschel, Bernard" uniqKey="Hirschel B" first="Bernard" last="Hirschel">Bernard Hirschel</name><name sortKey="Karrer, Urs" sort="Karrer, Urs" uniqKey="Karrer U" first="Urs" last="Karrer">Urs Karrer</name><name sortKey="Le Braz, Michelle" sort="Le Braz, Michelle" uniqKey="Le Braz M" first="Michelle" last="Le Braz">Michelle Le Braz</name><name sortKey="Nuesch, Reto" sort="Nuesch, Reto" uniqKey="Nuesch R" first="Reto" last="Nuesch">Reto Nuesch</name><name sortKey="Perneger, Thomas" sort="Perneger, Thomas" uniqKey="Perneger T" first="Thomas" last="Perneger">Thomas Perneger</name><name sortKey="Perrin, Luc" sort="Perrin, Luc" uniqKey="Perrin L" first="Luc" last="Perrin">Luc Perrin</name><name sortKey="Vernazza, Pietro" sort="Vernazza, Pietro" uniqKey="Vernazza P" first="Pietro" last="Vernazza">Pietro Vernazza</name><name sortKey="Yerly, Sabine" sort="Yerly, Sabine" uniqKey="Yerly S" first="Sabine" last="Yerly">Sabine Yerly</name></country><country name="France"><noRegion><name sortKey="Leduc, Dominic" sort="Leduc, Dominic" uniqKey="Leduc D" first="Dominic" last="Leduc">Dominic Leduc</name></noRegion></country><country name="Australie"><region name="Nouvelle-Galles du Sud"><name sortKey="Satchell, Claudette" sort="Satchell, Claudette" uniqKey="Satchell C" first="Claudette" last="Satchell">Claudette Satchell</name></region><name sortKey="Cooper, David" sort="Cooper, David" uniqKey="Cooper D" first="David" last="Cooper">David Cooper</name></country><country name="Royaume-Uni"><noRegion><name sortKey="Hill, Andrew" sort="Hill, Andrew" uniqKey="Hill A" first="Andrew" last="Hill">Andrew Hill</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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